The newest prescription drug Varenicline tartrate, also known as "Chantix", is the second nicotine-free smoking cessation drug available. Chantix works by reducing the pleasure of smoking and the withdrawal symptoms.

The tablet is to be taken twice, daily for 12 weeks, and this period can be doubled for clients who successfully quit smoking to increase their likelihood to stay smoke free. The most common side effects include nausea, vomiting, gas, insomnia, abnormal dreams, and change in taste perception.

This drug is available only by prescription.