The East Region serves 27 of Michigan's 83 counties in the eastern Lower Peninsula, including the metropolitan Detroit area (Lenawee, Macomb, Monroe, Oakland, Wayne, and Washtenaw counties). The Region provides uniform patrol, regional dispatch, and specialized investigative services for southeast Michigan through the First, Second, and Third Districts uniformed headquarters and the East Region Special Investigation Division.

The specialized investigative services provided by both the East and West Regions includes the areas of organized crime, white collar crimes, tax fraud, auto theft, fugitive apprehension, narcotics trafficking and interdiction, computer crimes, identity fraud, casino gaming, surveillance, violent crimes, cold case homicides, anti-terrorism, video enhancement, and electronic technical services. Nineteen multijurisdictional drug task forces composed of state, local, county, and federal agencies are supervised by the East and West Region Special Investigation Divisions.

1st District Headquarters

• Lansing Post #11
• Brighton Post #12
• Ithaca Post #14
  • Corunna Satellite #14
• State Capitol Post #16
• Jackson Post #17
• Adrian Post #18
  • Jonesville Satellite #18

2nd District Headquarters

• Metro North Post #21
  • Groveland Satellite #21
• Richmond Post #22
• Metro South Post #25
• Ypsilanti Post #26
• Monroe Post #28
• Detroit Post #29

3rd District Headquarters

• Bay City Post #31
• East Tawas Post #32
• Mt. Pleasant Post #33
• Flint Post #35
• West Branch Post #36
  • Gladwin Satellite #36
• Bridgeport Post #37
• Lapeer Post #38
  • Sandusky Satellite #38
• Caro Post #39
  • Bad Axe Satellite #39